Psychotic disorders in young patients with Prader-Willi syndrome: A case report and literature review

Introduction Prader-Willi syndrome (PWS) is a genetic disorder with an estimated prevalence of 1:25,000. PWS results from defective gene expression on the paternal copy chromosome 15. In 70% cases it deletion that means part 15 missing. Maternal uniparental disomy (mUPD) present in 25% cases. Typical clinical features are dysmorphism, hypotonia, hyperphagia, hypogonadism and developmental delay. addition, accompanied by various psychiatric symptoms often insufficiently known within field. Regarding relationship between schizophrenia spectrum disorders (SSDs), individuals mUPD appear to have 3 4 times higher risk psychotic than those subtype. Psychotic episodes atypical presentation recurrent confusion rapidly fluctuating mood symptoms. Objectives To describe unusual case order determine management regarding approach, provide overview patients for general practitioner most up-to-date information workup management. Methods We report involving 13-year-old woman (mUPD 15) mild intellectual disability (IQs 59), who presented symptomatology form disorganized behavior, delusional ideation, auditory hallucinations, self-referentiality suspicion. Parents reported these started two days prior day consultation. No environmentals stressors were identified no recent treatment changes made. Patient’s medication consists 150 mg sertraline per due anxiety control aid emotional behavioral regulation. Results Given diagnostic approach episode (PE) patient PWS, was decided offer 0.5mg risperidone day, increasing pattern until reaching final dose 1.25 presenting global remission symptomatology. Recommendations PE based upon systematic reviews. Patients especially subjects, at SSDs disorders. Antipsychotics (APs) gold standard SSDs, some authors suggested APs protect previous relapse. It unknown whether there protective effect not previously exhibited signs. Conclusions represents good example disease may be challenging treat psychotropic medications. For better understanding problems adults longitudinal studies careful standardized follow-up necessary. Disclosure Interest None Declared